Not prone to changing the distribution of fluid between compartments. Total body water is 60 of body weight and is divided into various body fluid compartments. Rapid mixing of tritiated water throughout all compartments occurs during a 3 to 4 hour equilibration period. Body fluid compartments can be measured by dilution of a compound that distributes only in the space of interest. 222 total body water. The indicator dilution principle is based on the definition of a concentration.
20150921 fluid compartments regulation of ecf volume fluid replacement duration. This is estimated by measuring the volume of distribution of isotopes of water. Body fluids can be discussed in terms of their specific fluid compartment a location that is largely separate from another compartment by some form of a physical barrier. If one were that way inclined one could also go on to read this indepth article by shoeller etal from 1980 full of thick juicy physiology. These include intracellular fluid and extracellular fluid. So simple one can describe it using only pictures.
If the amount of the substance is known and the resulting concentration is measured the volume can be calculated. Tritium oxide tho is used because it is a weak beta emitter making it easy to measure in a liquid scintillation counter. Extracellular fluid compartment further. Measuring total body water with radiolabelled tritium. University of kentucky department of anesthesiology 5062 views 2943. The intracellular fluid icf compartment is the system that includes all fluid enclosed in cells by their plasma membranes.